Jose Mourinho has picked his side to face Anderlecht at the Constant Vanden Stock Stadium, making three changes to the team that triumphed 3-0 at Sunderland last time out.
United face the Belgian side in the Europa League quarter-final first leg in Brussels, determined to take a big step towards reaching the last four of the competition.
Sergio Romero gets the nod in goal, as expected, with Matteo Darmian keeping his place but moving to left-back. Antonio Valencia returns on the right-hand side of the defence, Michael Carrick replaces Marouane Fellaini and Marcus Rashford starts in a wide attacking role, in preference to Ander Herrera.