The superb victory saw a number of significant milestones, such as two players scoring their first United goals, while we also equalled a 128-year club record.
After an afternoon on Merseyside packed full of incidents and highlights, we’ve rounded up a number of the major talking points from the match…
POTENTIAL FIFTH-ROUND OPPONENTS
The Reds' victory at Prenton Park means we have progressed to the fifth round of the FA Cup for the sixth season in a row. United will be joined in the last 16 by a number of familiar foes, with the likes of Leicester City, Chelsea and Manchester City in the hat for the next stage, along with Sheffield Wednesday, Portsmouth, Norwich City, Sheffield United and West Bromwich Albion.