A rare Sunday evening fixture involves a trip to Merseyside to face Frank Lampard's much-improved Everton but, before then, Erik ten Hag's team are in Europa League action against Omonia Nicosia in Cyprus.
There are many topics for debate in the wake of the Etihad Stadium loss, here are a few of the items for discussion among fans, in advance of the 17:45 BST kick-off on Thursday...
DEFENSIVE INJURIES
Raphael Varane hurt his ankle in the derby and was forced to withdraw during the first half, after blocking a shot from Phil Foden. We await an update on the France international but, hopefully, it is not too serious.