Ruben Amorim's Reds face a third away league game since the turn of the year, following the 2-2 draw at Liverpool and 1-0 victory at Fulham.
Spurs currently sit one place and two points behind United in the table, in 14th spot, with both teams experiencing difficult top-flight campaigns. While we progressed in the Emirates FA Cup last time out, Ange Postecoglou's men crashed out at Aston Villa.
The two English sides in the Europa League can only meet each other in the final in Bilbao, as the Reds and north Londoners await the outcome of the play-offs in the competition.