While the Reds have in-form options in abundance going forward, after Tuesday’s impressive 4-1 beating of Istanbul Basaksehir, the squad is a little more stretched in defence, with three-quarters of Ole Gunnar Solskjaer’s most-picked back four this season out or doubtful.
Luke Shaw remains on the sidelines, with the left-back expected to return in mid-December after suffering a hamstring injury earlier this month.
Aaron Wan-Bissaka, who celebrates his 23rd birthday on Thursday, was substituted early in midweek, as was centre-back Victor Lindelof.
Ole’s comments on the pair after the final whistle suggested the changes were precautionary ahead of the clash with the Saints, but Lindelof has been struggling with a back problem in recent weeks, so it remains to be seen whether he’ll be present for the game on the south coast.