The Reds’ confidence should be high as we head into the weekend clash on the back of three successive wins in all competitions.
Southampton are also enjoying a good run of form and currently occupy a Europa League position after an excellent start to the campaign.
Our must-read match preview provides you with all the need-to-know details about this crucial Premier League meeting.
ESSENTIAL INFO
Kick-off at St Mary’s will take place at 14:00 GMT and fans in the UK can watch the game on Sky Sports Main Event and Sky Sports Premier League.