It's United's first game for two weeks, although much of the squad have been kept busy over the last fortnight playing for their respective countries.
Luke Shaw, who had been struggling with injury and illness prior to the break, came through England's 1-1 draw with Hungary on Tuesday night but his fellow England defender Harry Maguire was not selected in the Three Lions squad, as a result of the calf issue he picked up during the defeat to Aston Villa.
Maguire has not been involved since, and fellow centre-back Raphael Varane suffered a groin problem while playing for France and will be out for a few weeks, meaning Victor Lindelof and Eric Bailly are likely to feature in the East Midlands.