A campaign that began 11 months ago ends with the trip to Leicester City, with a place in the top four, and next term's Champions League, at stake.
United need at least a point to finish above the Foxes but defeat would leave the Reds relying on Wolves to spring a major surprise at Chelsea's Stamford Bridge by beating the Blues.
The boss has elected to go with a tried and tested formula by reintroducing Aaron Wan-Bissaka into the side, in place of Tim Fosu-Mensah. On the opposite flank, Brandon Williams continues to deputise for injured left-back Luke Shaw.