Goalkeeper Sergio Romero comes back into the team for his third Europa League start of the season.
Juan Mata, Marcos Rojo and teenager Mason Greenwood make up the quartet who were not part of the starting XI at the Vitality Stadium in the 1-0 defeat.
The manager has also retained a similar look to his side that beat Partizan 1-0 last month in Belgrade, thanks to Anthony Martial’s penalty winner just before half-time.
Seven players who began the match in the Partizan Stadium start again tonight at Old Trafford in the Group L match.
Marcus Rashford didn’t make the starting XI in Belgrade but came on for goalscorer Martial.