The two forwards have been in spellbinding form so far this season, and both notched the winning goals in 3-2 victories for their sides in the Champions League earlier this week.
Ronaldo's dramatic late header helped the Reds come from two down to beat Atalanta at the Theatre of Dreams, while a Salah double fired Liverpool to success against 10-man Atletico Madrid at the Wanda Metropolitano.
But this will be the first time that the pair have faced off in a United-Liverpool dust-up, and both Ole Gunnar Solskjaer and Jurgen Klopp were asked about that prospective duel in their Friday afternoon press conferences.