The Reds faced the Royals at home on the opening day of last season, with United running out 2-0 winners thanks to goals from Kirsty Hanson - now on loan at Aston Villa - and Ona Batlle.
But despite doing the league double over Reading in 2021/22, Skinner maintains that his squad - bolstered by seven summer additions - will need to be at their best to continue their recent successes over the Berkshire side.
Ahead of the eagerly anticipated WSL curtain-raiser, which is due to kick-off at 12:00 BST, the United Women boss sat down with club media to discuss our opponents and his ambitions for the season ahead.