The left-back was hurt after an awkward landing when challenging Rodri in the air and required treatment on the pitch.
Although he was able to resume, he then needed to go ground again and was replaced by Alex Telles with 17 minutes remaining.
The defender has been named in the England squad for the upcoming World Cup qualifiers against Albania next Friday and San Marino (Monday 15 November).
However, whether he will link up with Gareth Southgate's side will depend on an assessment of the problem and a check on the concussion, that led to United making four substitutions.