The two former midfielders, who have more than 1,000 first-team appearances between them, have been announced as the first names in Bryan Robson's squad.
Our Reds team will take on a Celtic XI managed by Paul Lambert at Old Trafford on Saturday 7 September, to raise money for Manchester United Foundation. Further star names will be revealed in the coming weeks.
Tickets are on sale now to all supporters.
United and Celtic have met competitively just four times, but the two clubs have enjoyed a close relationship for many decades.
The Scottish club became the first British club to lift the European Cup in 1967, and United opened England's account the following year.