There are four changes in total to the team that began the 2-0 loss at Arsenal on Wednesday night.
Lisandro Martinez and Kobbie Mainoo return to the squad, and the starting line-up, after serving one-game bans in the game at the Emirates Stadium.
Leny Yoro makes his maiden Old Trafford appearance, and first start, since his summer move from Lille. Matthijs de Ligt is the other central defender, while Amad is reinstated as right wing-back.
Noussair Mazraoui, Tyrell Malacia, Harry Maguire and Mason Mount move to the bench.
it is a powerful-looking list of substitutes, with a host of options, across all positions.