The Giallorossi face an uphill task in the Italian capital and will need to score at least four goals if they are to overturn United’s significant lead from last week’s memorable game in Manchester.
The Reds ran riot at Old Trafford, netting five times after the break to secure a 6-2 win, while Roma were left counting the cost of the trip after losing several members of their travelling party to injury.
Goalkeeper Pau Lopez, defender Leonardo Spinazzola and midfielder Jordan Veretout all had to be substituted during the first half in M16 and the trio are not available for this game.