Erik ten Hag has selected Noussair Mazraoui in his starting XI, meaning the Morocco international enjoys a United debut three days after signing from Bayern Munich.
Fellow summer arrivals Matthijs de Ligt and Joshua Zirkzee have been named among the substitutes, and would also be making their Reds bows if called upon.
The trio, along with Leny Yoro, will be introduced to the crowd prior to kick-off.
Mazraoui replaces Jonny Evans in the only change from Saturday's Community Shield meeting with Manchester City at Wembley.
That means that, ahead of Andre Onana, Harry Maguire partners Lisandro Martinez in defence, with Diogo Dalot the other full-back in the team.