The TV slots have already been selected for the opening round of fixtures and it means viewers in the UK will be able to watch the dawning of a new era at Old Trafford.
United won last year's contest with the Seagulls 2-0 in February, after it was initially postponed due to a Covid-19 outbreak at Carrington. Cristiano Ronaldo and Bruno Fernandes scored the goals in the second half, while Lewis Dunk was sent off.
The Reds will be looking to avenge the defeat at Brighton in our penultimate game of last term.
It represents a sixth successive home opener for United, with our last start on the road taking place in 2016, at Bournemouth, with a 3-1 victory recorded in Jose Mourinho's first league game in charge.