It was the Reds' first Premier League loss of the season with Villa’s Kortney Hause heading in the vital winner in the 88th minute.
United had a golden chance in added-on time as a House handball presented Fernandes with a spot-kick chance to snatch a point. But our Portuguese midfielder unfortunately skied the 12-yard shot into the crowd.
Manager Ole Gunnar Solskjaer had reverted back to his league XI that had beaten West Ham in London last Sunday following the defeat here to the Hammers in midweek in the Carabao Cup.
But Villa proved a stubborn opponent and despite United finishing with an attack of Cristiano Ronaldo, Edinson Cavani and Mason Greenwood, we just couldn’t find the net and slipped to defeat.