Villa had managed to frustrate the Reds at Leigh Sports Village in the 0-0 reverse fixture in November, but plenty has changed for today's struggling hosts since then and this was a sixth straight league defeat for them.
Marc Skinner, celebrating his 42nd birthday in his home city, made one change from the side that started the defeat to Liverpool, with Hinata Miyazawa replacing Dominique Janssen in midfield.
Elisabeth Terland's eighth and ninth goals of this WSL campaign got the ball rolling for United, with Grace Clinton making it 3-0 by half-time with a contender for goal of the season.