It's a quick turnaround for the Reds, who are in action on Saturday lunchtime, visiting Southampton in the first Premier League game to be played following the break.
The meeting at St Mary's Stadium kicks off at 12:30 BST and will be broadcast live on TNT Sports in the UK.
There's an opportunity for United to put defeats against Brighton & Hove Albion and Liverpool behind us and set a marker, ahead of a busy period of fixtures featuring seven games in 22 days, across three competitions.
Several players who were involved for their countries during the past week were photographed on Thursday, including Bruno Fernandes, who made his 600th career appearance as Portugal secured a 2-1 victory over Scotland.