Interim manager Ralf Rangnick will take charge of the side for the last time, before handing over the reins to incoming boss Erik ten Hag, and he could be able to call upon Luke Shaw again.
The left-back had appeared to be ruled out for the remainder of the campaign when having surgery to remove metal bolts from his leg.
However, he was back out on the grass on Tuesday with his colleagues, after being absent since the draw with Leicester City on 2 April.
Fellow England internationals Jadon Sancho and Marcus Rashford could also return to the matchday squad after illness.