It's been an interminable wait for many loyal Reds, some of whom have been following the team home and away for decades.
One such supporter is Steve Black, who has been following the club since the 1970s, and now attends every game with his son, Luca, 15.
And while United matches continued behind closed doors throughout the pandemic, Black says nothing can replace the feeling of returning to stadiums and, in particular, away grounds.
“We are so giddy about going down to Southampton,” he smiles, “The hyper feeling we've got about Sunday and getting back into those real strong relationships and bonds that we've formed over the years, we're just so excited.