The Reds earned an impressive 4-1 win in the first leg at Old Trafford, thanks to goals from Marcus Rashford, Antony, Bruno Fernandes and Wout Weghorst.
Our three-goal victory provides a firm grasp on the tie and Ten Hag might be tempted to rotate his team in Spain, with another important match to come on Sunday against Fulham in the Emirates FA Cup quarter-final.
We should glean an insight into the manager's plans via Wednesday's pre-match events, of course. Here's what is coming up...
TRAINING
United will train at Carrington on Wednesday morning from 9:30 GMT and the first 15 minutes will be open to the European football media, as per UEFA rules.