Following a comprehensive 4-1 victory at Old Trafford a week ago, the Reds followed it up with a 1-0 win away from home to book a place in the last eight of the competition.
A frantic, end-to-end second leg would see both goalkeepers playing key roles, but, ultimately, it was a stunning strike from Marcus Rashford that would prove to be the difference-maker tonight.
Erik ten Hag’s side are now into the hat for the next round, with the draw scheduled to take place on Friday at 12:00 GMT.
FIRST HALF – END TO END
Both United and Betis were welcomed into a roaring Estadio Benito Villamarin in Seville, and while the hosts were the side in need of a fast start, it was the Reds who surged forward from the first whistle.