The reigning club and Premier League Player of the Month opened the scoring in the first leg of the round-of-16 tie at Old Trafford, with a bullet drive high into the net, after showing real composure to get his shot away.
That was goal number 26 for the Reds this season, 29 if you count his three for England at the World Cup finals, and he will be hoping to continue his fine record in Spain in the 17:45 GMT kick-off.
Rashford's first United goal in Spain was an important one - the cracking free-kick which proved to be the only goal of the game in the Europa League semi-final first leg, back in 2017.