It’s a game that not only dictates bragging rights between cities but historically has proved to be a bellwether in terms of who dominates English football.
We have a mixed record in L4 over the years, but the fixture has provided some memorable moments for fans of all ages.
Here are five of the most unforgettable from the Premier League era…
MAGIC MATA MAKES HIS MARK
In March 2015, Juan Mata produced a moment of magic with a stunning scissor kick on a tight angle to squeeze the ball past a bewildered Simon Mignolet.