The Reds are playing in front of the Elland Road fans for the first time since 2003, when Cristiano Ronaldo helped Sir Alex Ferguson's side silence the crowd with a 1-0 win, thanks to Roy Keane's late goal.
This fixture ended 0-0 last term, when played behind closed doors due to the COVID-19 pandemic, but United have won both home games convincingly against the Whites since their return to top-flight football.
Unfortunately, striker Edinson Cavani is still unavailable, despite returning to training. The Uruguay international will not be an option in attack but may hope to return for the trip to Spain to face Atletico Madrid in the Champions League in midweek.