Will the boss give debuts to either Patrick Dorgu or Ayden Heaven, or both, and who might come in for the injured Lisandro Martinez? These are the key questions up for debate ahead of the 20:00 GMT kick-off against Leicester City, managed by Reds great Ruud van Nistelrooy.
Ahead of an Old Trafford night under the lights, we’ve been playing our popular United Predictions game alongside MUTV pundits Wes Brown and Danny Simpson, who won six Premier League titles between them in their careers. Join in guessing who will replace Licha, whether Ruben might give a starting spot to either of his new options and who might start up front after Kobbie Mainoo’s impressive recent displays in attacking positions.