Erik ten Hag's Reds are looking to finish strongly against another one of our European-chasing rivals: the Magpies are currently two places ahead in the table with just two top-flight games left to play.
Ahead of 20:00 BST kick-off, two former Reds defenders and current MUTV pundits have shared their United Predictions.
Before you play the predictions game for yourself, take a look at what the lads have backed...
PHIL BARDSLEY'S PREDICTIONS
The former United defender sees Ten Hag making multiple changes to his starting XI, with Amad playing a starring role against the Magpies.