Erik ten Hag's side will be looking to bounce back following our Premier League defeat against Spurs on Sunday, having gone down 3-0 on home soil.
But with the onus firmly on returning to winning ways, the Reds are likely to have our work cut-out against stern opposition.
Ahead of the encounter, MUTV's very own Wes Brown and Phil Bardsley have provided their thoughts on how they see the game panning out across the 90 minutes.
Scroll down a little further to indulge in some essential pre-match reading from two players who know a thing or two about donning the Red shirt on big occasions.