The 20:00 GMT kick-off provides an opportunity for the Reds to continue a strong start to 2025, with a creditable draw at Anfield against Liverpool and a memorable penalty shoot-out win in the Emirates FA Cup over Arsenal.
It’s the circumstances of that latter game which provides the first clear debate for Amorim, with full-back Diogo Dalot being sent off 61 minutes in. He’s thus suspended for our game with Southampton.
Ahead of another Old Trafford night under the lights, we’ve been playing our popular United Predictions game alongside MUTV pundits Wes Brown and Ben Thornley. Join in guessing who will replace Diogo, and whether Ruben might give a starting spot to those who impressed off the bench at the Emirates Stadium, like Toby Collyer, Leny Yoro and Tyrell Malacia.