Correctly predicting Erik ten Hag’s line-up, the final score, our first goal-getter and Man of the Match in the teatime fixture will put you in with the chance of winning some amazing prizes.
You can play now via the United App, where you have until kick-off at 17:30 GMT on Saturday to submit your picks. Although, please note that your line-ups guess must be entered by 16:00 GMT.
Former United defender and MUTV pundit Wes Brown is among those playing our predictions game and he has shared his picks before appearing on our Matchday Live show tomorrow, including the XI he thinks the boss will select.