Marc Skinner’s side welcome FA Premier Division North side Newcastle United on Sunday 14 January for a 12:00 GMT kick-off.
It is the first time these two sides have met, and with a passionate fan base backing each team, it is set to be an electric encounter.
Ahead of Sunday’s showpiece, here are the key things to know…
HOW CAN I WATCH THE GAME? We will air live radio commentary on ManUtd.
Kicking off at 12:00 GMT, the game will be shown live on The FA Player.