It's also our penultimate fixture of the season, as Marc Skinner’s Reds continue to chase the Women’s Super League title, with reigning champions Chelsea now at the summit.
We’ll be going all out to secure three points in the derby and tee up one last push against Liverpool on the final weekend.
Ahead of Sunday's game, here are the key things to know from live broadcast details to team news…
HOW CAN YOU WATCH AND FOLLOW THE GAME?
The Manchester derby kicks off at 18:45 BST on Sunday 21 May and will be aired live on Sky Sports for fans in the UK and Ireland.