After a successful trial in the Emirates FA Cup this term, the process will be introduced across top-flight matches this weekend.
Our fixture awa to Carabao Cup winners Newcastle United is set for a 16:30 BST kick-off.
The technology was also tested non-live in the division and is being used to help provide support for VAR in making quicker calls when it comes to offside.
It relies on optical player tracking and virtual graphics to provide swifter and clearer placing of the lines involved in the decision-making process.
The Premier League stated that it has "worked in collaboration with PGMOL (Professional Game Match Officials Board) and sports data and technology company Genius Sports" to develop the new system.