United require victory to secure an automatic berth in March's round of 16, while a draw and even a defeat could also suffice, depending on results elsewhere. Should we fail to make the top eight, there is always the play-off round, which gets under way in two weeks' time.
Fans around the world have been making their calls ahead of kick-off in Bucharest, as they bid to register the top score and win some incredible prizes, including a signed shirt.
If you were unsure as to what to select when it comes to correct score and Man of the Match, here are some of the most popular predictions:
Correct score: FCSB 0-2 United (22.