The 21-year-old was named in the starting line-up for Marcelo Bielsa’s first game in charge of the South American side, at Estadio Centenario in Montevideo.
Pellistri has been a regular for his national team and that looks set to continue under the guidance of the former Leeds United manager.
The winger was involved in two of Uruguay’s four goals in a 4-1 home triumph over Nicaragua on Wednesday evening.
Facundo’s first assist of the night came inside the opening 10 minutes, when he teed up Matias Arezo after making an undetected run at the back post.