The United winger started the fixture at the Allegiant Stadium in Las Vegas and was his energetic self as La Celeste vied to continue the impressive form they have shown stateside.
Both nations battled hard, with clear-cut chances coming at a premium and, after 74 minutes, Uruguay right-back Nahitan Nandez was issued a straight red card.
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Pellistri was replaced four minutes later by Guillermo Varela and, despite being a man down, Marcelo Bielsa's side forced extra-time.