Betis will be the 12th Spanish team we've faced in continental competition so, naturally, this makes for an exciting issue of our matchday programme, United Review.
Inside, you'll get the full lowdown on the Seville club, who are managed by former Manchester City boss Manuel Pellegrini and are currently enjoying one of the best spells in their recent history.
But, of course, our main focus is United, and there's plenty of cracking content...
All eyes will be on the exclusive manager's column from Erik ten Hag, as the Dutchman gives us his thoughts on Sunday's humbling result at Anfield and his plans for a strong response.