It's a disappointing blow for the pair, especially given the close proximity of the mid-season World Cup in Qatar.
But, in truth, what more could Rashford and Sancho have done during the season's early weeks?
The former has scored three goals and provided two assists, while the latter scored his third of the season in the 2-0 win over Sheriff on Thursday.
We're barely midway through September, but both Rashford and Sancho are already close to equalling their goal tallies from the entirety of United's disappointing 2021/22 campaign.
But the positive for both players is that time is still on their side, and the positive for United fans is that it leaves the duo with even more time to work with Erik ten Hag at Carrington during the upcoming international break.