Paul Pogba was injured during the international break, while Marcus Rashford, Luke Shaw, Scott McTominay and Edinson Cavani were also unable to represent their respective countries as the World Cup qualifying campaign continued.
Raphael Varane was already sidelined as the club prepares for a key stage of the season with so many games on the schedule as we approach the end of the calendar year.
"I've got to say this week has been really positive," the manager said at his press conference. "Of course, there are a couple of doubts with illnesses and small niggles.
"Paul is out still for a while, Raphael is out for a while still.