The Old Trafford encounter, which kicks off at 15:00 BST, provides another opportunity for the Reds to push towards third and fourth place, following the latest round of matches, with Ole's men now in fifth spot.
Defenders Phil Jones and Axel Tuanzebe are definitely ruled out, with the manager providing a more detailed timeframe on a likely return following their continued absence since the return to football last month.
The Reds are on a 15-game unbeaten run and looking to avenge the 1-0 defeat at the Vitality Stadium earlier in the campaign. Bournemouth slipped to 19th in the table in midweek but are only a point from safety, despite losing all three fixtures since the restart.