The away leg will be held at the Allianz Arena in Turin as the Reds are hoping to go all the way and repeat the success in the competition in 2017, when Ajax were defeated 2-0 in Stockholm.
Not only will Donny van de Beek and Edinson Cavani fail to make the flight to Italy but there are question marks over the involvement of Scott McTominay and Anthony Martial against the Basque side.
Paul Pogba remains on the sidelines and the boss has confirmed the France international will not be back before March at the earliest.
“Paul is recovering well,” explained the manager at a press conference.