The Uruguay striker is serving the second part of his three-game suspension and will also sit out Saturday's Emirates FA Cup third-round encounter with Watford.
Reds boss Ole Gunnar Solskjaer provided an update on the shape of his squad ahead of the midweek encounter with the Blues, and Victor Lindelof should be fit again after suffering a recurrence of a back problem.
“We're disappointed not having Edinson involved,” said Ole. “But he's probably the only one not [available] and, of course, Phil Jones has been out for a long time. They're the only two not available for selection, which is a good position to be in.