The United manager admitted at his pre-match press conference that he faced a dilemma over who to pick in goal and he has gone for Sergio Romero between the posts.
The back four is made up of Aaron Wan-Bissaka, Eric Bailly, captain Harry Maguire and Brandon Williams, who penned a new United deal last week.
In front of them, Fred anchors the midfield alongside Paul Pogba, while Bruno Fernandes once again supports the in-form attacking trio of Mason Greenwood, Marcus Rashford and Anthony Martial.
The Reds have 12 substitutes, including the likes of David De Gea, Victor Lindelof, Jesse Lingard and Odion Ighalo.