The Frenchman was withdrawn in the first half of the 2-2 draw with Atalanta in the Champions League in midweek, and a hamstring injury will rule him out for around a month.
Fellow centre-back Victor Lindelof missed the trip to Italy with a knock sustained in training and the boss admits he is playing a waiting game over selecting the Sweden skipper for a huge encounter at Old Trafford, which kicks off at 12:30 GMT.
“We’ve got a couple of players doubtful unfortunately, but that’s part of the game," explained Ole to club media's Zarah Connolly at Carrington.