Cavani has appeared in each of United's last four games, but suffered an issue during the week which means he has been ruled out of the clash with Pep Guardiola's side at Old Trafford. The South American has not been named in Uruguay's latest international squad due to the fitness concerns.
Rashford is in good form, having netted three goals since making his return from shoulder surgery last month, but Solskjaer revealed he had faced a race against time to be fit.
Marcus has been included on the bench, with Mason Greenwood taking his place in the starting XI, but Ole says our no.