The two old rivals clash in the tie of the round as Neil Ryan's boys look to emulate home-and-away wins over the Merseysiders at league level this term.
Joe Hugill scored twice as the Reds came from behind to win 4-3 in December before Charlie McNeill's goal was enough to settle the match at the Liverpool Academy last month.
Ryan selected a very inexperienced squad for the 2-0 triumph at Salford City in the previous round with schoolboy Daniel Gore heading the opening goal before McNeill made certain of progress. Liverpool overcame Sutton United at the same stage.