The Reds and the Seagulls both started the 2024/25 campaign in the best way possible, with wins on Friday and Saturday, respectively.
Joshua's Zirkzee's late goal earned victory over Fulham for United, before Brighton defeated Everton, 3-0 in their own backyard the following day.
Excitement is building towards Saturday's 12:30 BST kick-off already and, as we count down to our first away fixture of the new season, get all the info from broadcast details to early team news and more...
HOW CAN I WATCH THE GAME?
The lunchtime kick-off will be broadcast live on TNT Sports, with their coverage beginning 11:00 BST.