The 24-year-old signed a new contract in the summer, keeping him at Old Trafford until June 2023 with the option to extend by another year.
Axel, who has been with United since joining the Academy at the age of eight, then immediately embarked on a third loan spell with Aston Villa, having previously played for the Midlands club in two Championship campaigns.
Tuanzebe made 11 appearances for the Villans - who we now face twice in succession - in the first half of this season, with nine of those games coming in the Premier League.